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ActivaMune Diindolylmethane (DIM) Natural Immune Booster
  • Introducing ActivaMune with Patented
    Technology from UC Berkeley

  • Diindolylmethane (DIM)
    Immune, Breast, Prostate, Colon & Skin Health

  • Sulforaphane
    Cellular Detoxification

  • Selenium
    Immune, Breast, Prostate & Vision Health

  • Lycopene
    Cardiovascular, Breast & Prostate Health

  • Lutein
    Immune, Vision & Prostate Health

  • Zeaxanthin
    Vision Health

  • Vitamins C, D3, E and Calcium
    Immune Support & Bone Health

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Diindolylmethane DIM Natural Immune System Booster

 

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If you wish to sign up for the ActivaMune Newsletter, providing the latest scientific updates in the field of molecular nutrition, please e-mail the following address with your name and contact information and it will be our pleasure to add you to our growing list of nutrition enthusiasts. Please write "Newsletter" in the subject line of your e-mail address to be added to the list.

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Important note for readers: while many of the scientific discoveries and clinical developments listed in this section are extremely exciting, they are stepping stones in the studies of Diindolylmethane (DIM) and some of the other key natural ingredients in ActivaMune. The exploration of clinical applications for Diindolylmethane is an emerging science. Only the US FDA has the authority to recognize a compound as a drug or therapeutic for a particular condition in the US and that only occurs after the compound has been thoroughly studied and its efficacy established in four consecutive human clinical trials. At this point in time, Diindolylmethane and the other natural ingredients in ActivaMune are regarded as dietary supplements and not therapeutics for any specific condition by the US FDA. ActivaMune is a nutritional supplement. The statements on this website have not been evaluated by the US Food and Drug Administration. ActivaMune is not intended to diagnose, treat, cure or prevent any disease.

US Department of Agriculture scientists elucidate how Diindolylmethane's anti-inflammatory properties help to promote prostate health. Indole-3-Carbinol and 3',3'-Diindolylmethane Modulate Androgen's Effect on C-C Chemokine Ligand 2 and Monocyte Attraction to Prostate Cancer Cells. Cancer Prev Res (Phila). 2013 Jun;6(6):519-29. doi: 10.1158/1940-6207.CAPR-12-0419. Kim EK, Kim YS, Milner JA, Wang TT. U.S. Department of Agriculture, Building 307C, Room 132, BARC-EAST, 10300 Baltimore Ave., Beltsville, MD 20705

Scientists in Germany discover that Diindolylmethane (DIM) potentiates molecular pathways that slow down the aging process and promote life extension. Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension. Aging Cell. 2013 Mar 23. doi: 10.1111/acel.12077. Stephan J, Franke J, Ehrenhofer-Murray AE. Zentrum für Medizinische Biotechnologie, Universität Duisburg-Essen, Essen, Germany.

Scientists at the Karamos Cancer Institute discover that naturally occurring Diindolylmethane (DIM) enhances the effectiveness of Herceptin--leading therapeutic for breast cancer. 3,3'-diindolylmethane Enhances the Effectiveness of Herceptin against HER-2/Neu-Expressing Breast Cancer Cells. PLoS One. 2013;8(1):e54657. Epub 2013 Jan 22. Ahmad A, Ali S, Ahmed A, Ali AS, Raz A, Sakr WA, Rahman KW. Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America.

Scientists demonstrate that Diindolylmethane (DIM) promotes cervical health. Anti-proliferative and pro-apoptotic effects of 3,3'-diindolylmethane in human cervical cancer cells. Oncol Rep. 2012 Sep;28(3):1063-8. doi: 10.3892/or.2012.1877. Zhu J, Li Y, Guan C, Chen Z. Department of Gynecology, Renmin Hospital of Wuhan University, Wuchang, Wuhan 430060, PR China.

Biomedical investigators elucidate that Diindolylmethane (DIM) inhibits the development of cancer stem cells, paving the way for the human clinical trials of DIM as a cancer preventive natural compound. Diindolylmethane (DIM) selectively inhibits cancer stem cells. Biochem Biophys Res Commun. 2012 Jul 20;424(1):45-51. Semov A, Iourtchenco L, Lin Fang L, Shengmin L, Xu Y, Su X, Muyjnek E, Kiselev V, Alakhov V. Montreal, Quebec, Canada.

 

Phase I human clinical studies of Diindolylmethane (DIM) as a therapeutic candidate for castrate-resistant non-metastatic prostate cancer patients demonstrated efficacy. DIM has now progressed to Phase II human clinical studies. The recommended dosage for the Phase II study is approximately 2x the DIM concentration in ActivaMune. (In order for a therapeutic candidate to receive recognition as a treatment for a particular condition by the US FDA, it must pass four progressive phases of human clinical trials. DIM is currently regarded as a dietary supplement and not a therapeutic for any condition.) A phase I dose-escalation study of oral DIM (3,3'-Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am J Transl Res. 2010 Jul 23;2(4):402-11.  Heath EI, Heilbrun LK, Li J, Vaishampayan U, Harper F, Pemberton P, Sarkar FH. Karmanos Cancer Institute, Wayne State University Detroit, MI, USA.
 

In a landmark preclinical study at UC Berkeley, Diindolylmethane (DIM) is shown to promote cellular prostate health. UC Berkeley Publication. 3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. Biochemical Pharmacology. 2009 Sep 1;78(5):469-76. Epub 2009 May 9. Vivar OI, Lin CL, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 94720-3104, USA.
 

Scientists at the Barbara Ann Karmanos Cancer Institute publish their findings regarding Diindolylmethane (DIM) and its potential as a dietary supplement. Cancer Treatment Review. 2009 Aug 4. Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics. Sarkar FH, Li Y. Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.

 

In a breakthrough preclinical study, biomedical investigators at the Genomics Institute of Novartis Research Foundation elucidate a novel biological property of Diindolylmethane (DIM) and its relevance to cardiovascular health. Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. Journal of Biological Chemistry 2009 May 1;284(18):12328-38. Epub 2009 Mar 13. Yin H, Chu A, Li W, Wang B, Shelton F, Otero F, Nguyen DG, Caldwell JS, Chen YA. Genomics Institute of the Novartis Research Foundation, San Diego,
California 92121, USA.

 

Diindolylmethane (DIM) is a potent activator of the immune response system in-vivo - UC Berkeley Publication. Scientists demonstrate for the first time that DIM modulates four key cytokines in-vivo: Interferon-Gamma (IFN-G), Granulocyte Colony Stimulating Factor (G-CSF), Interlukin-12 (IL-12), and Interlukin-6 (IL-6). IFN-G is responsible for the entire immune response system. G-CSF is responsible for White Blood Cell production in the body. IL-6 is responsible for the body's direct anti-bacterial response. IL-12 stimulates the growth and function of T-Cells which help to fight off pathogens. This key publication marks the birth of a global effort to study DIM as a potent natural therapeutic candidate for most forms of cancer, most viral infections and most bacterial infections. According to Dr. Gary Firestone, Director of the National Institutes of Health Cancer Research Program and co-author of the study at UC Berkeley, "This study shows that there is a whole new universe of molecular biology related to DIM....there are no other agents known that can both directly promote apoptosis and enhance the function of the immune system at the same time." 3,3′-Diindolylmethane stimulates murine immune function in vitro and in vivo,  Xue L, Pestka J, Maoxiang L, Firestone GL, Bjeldanes LF,  Journal of Nutritional Biochemistry, published online, 8-20-07. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 94720-3104, USA.

 

Diindolylmethane (DIM) activates and potentiates interferon-gamma signaling in human cells - UC Berkeley Publication. Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells. Molecular Pharmacology. 2006 Feb;69(2):430-9. Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 94720-3104, USA.

 

Diindolylmethane (DIM) stimulates Interferon-Gamma gene expression in human cells - UC Berkeley Publication. DIM stimulates IFNgamma gene expression in human breast cancer cells via the specific activation of JNK and p38 pathways. Xue L, Firestone GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720-3104, USA. Oncogene. 2005 Mar 31;24(14):2343-53.

 

Diindolylmethane (DIM) supplementation in humans increases the 2-hydroxylation of estrogen metabolites - UC Berkeley Publication. As 2-hydroxylation of estrogen metabolites is a process that scientists believe helps to reduce the risk of breast and prostate cancer, this human clinical study on DIM's effect on estrogen metabolites made headline news world-wide and added to the popularity of DIM as a nutritional supplement. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Journal of Nutrition and Cancer. 2004;50(2):161-7. Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF Department of Molecular and Cell Biology, University of California, Berkeley, 94720-3200, USA.

 

Biomedical researchers in Europe and the United States, after studying over 10,000 women, confirm that 2-hydroxylation of estrogen metabolites reduces the risk of breast cancer. Estrogen metabolism and risk of Breast cancer: A prospective study of the 2:16α-hydroxyestrone ratio in premenopausal and postmenopausal women. Epidemiology, 2000, vol. 11, no6, pp. 635-640 Muti P, Bradlow HL, Micheli A, Krogh V,  Freudenheim JL,  Schunemann HJ, Stanulla M, Jun Y,  Sepkovic DW, Trevisan M, Berrino F. Department of Social and Preventive Medicine, University at Buffalo, State University of New York at Buffalo, Buffalo, NY, USA, Epidemiology Division of the National Cancer Intitute (Istituto Nazionale Tumori), Milan, Italy, Department of Pediatric Hematology and Oncology, Medical School of Hannover, Hannover, Germany.

 

A preclinical study shows that Diindolylmethane (DIM) synergizes with Paclitaxel (Taxol) - Thomas Jefferson University Publication. Biomedical investigators at the Jefferson Medical College have demonstrated that DIM synergizes with the number one selling cancer drug worldwide, Paclitaxel (Taxol)--a phytochemical extracted from the Pacific Yew Tree. Their paper was published in the Journal of Surgical Research. 3,3′-Diindolylmethane and Paclitaxel Act Synergistically to Promote Apoptosis in HER2/Neu Human Breast Cancer Cells. Journal of Surgical Research, 2006 May 15;132(2):208-13. K. McGuire, N. Ngoubilly, M. Neavyn, S. Lanza-Jacoby Department of Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

 

Biomedical scientists find that cruciferous vegetable intake reduces the risk of late stage prostate cancer by up to 52%. Prospective Study of Fruit and Vegetable Intake and Risk of Prostate Cancer. Journal of the National Cancer Institute. 2007 Jul 24; (Epub ahead of print) Krish VA, Peters U, Mayne ST, Subar AF, Chatterjee N, Johnson CC, Hayes RB. Click here for the BBC Report covering this publication.

 

Biomedical investigators publish their findings linking high Brassica vegetable consumption with a 40% reduction in the risk of breast cancer development. Brassica Vegetables and Breast Cancer Risk. Terry P, Wolk A, Persson I, Magnusson C,  (2001). JAMA 285 (23): 2975-2976.

 

A preclinical study at UC Berkeley demonstrates that Diindolylmethane (DIM) promotes cellular breast health - UC Berkeley Publication. 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. Hong C, Kim HA, Firestone GL, Bjeldanes LF. Carcinogenesis. 2002 Aug;23(8):1297-305. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA.

 

Broccoli sprouts found to boost the body's ability to eliminate toxins in human study by investigators at the Johns Hopkins School of Medicine. Cancer Epidemiology Biomarkers and Prevention. 2005 Nov. 14 :2605-13. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Talalay P, Fahey JW. Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Room E7541, 615 North Wolfe Street, Baltimore, MD 21205, USA

 

US medical researchers publish findings linking Calcium and Vitamin D3 intakes with up to a 77% reduction in cancer risk relative to placebo controls. Vitamin D and Calcium supplementation reduces cancer risk: results of a randomized trial. American Journal of Clinical Nutrition. 2007 Jun:85(6): 1586-91. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA.

 

Molecular biologists publish findings that Vitamin D3 boosts the immune system by promoting the production of cathelicidin antimicrobial peptides. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005 Jul;19(9):1067-77. Gombart AF, Borregaard N, Koeffler HP. Department of Medicine, Division of Hematology/Oncology, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA

 

Scientists discover that selenium blocks NFkB activity. NFkB inhibits apoptosis and promotes inflammation. High selenium reduces NF-kappaB-regulated gene expression in uninduced human prostate cancer cells. Christensen MJ, Nartey ET, Hada AL, Legg RL, Barzee BR, Journal of Nutrition and Cancer, 2007;58(2):197-204. Department of Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT 84602, USA.

 

United States Department of Agriculture scientists publish an important review of selenium as a nutrient. Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion. Zeng H, Combs GF Jr., 2007 Jun 22, Journal of Nutritional Biochemistry. United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, P.O. Box 9034, Grand Forks, ND 58202-9034, USA.

 

Researchers at Johns Hopkins determine that women with low serum selenium and total carotenoids have higher mortality rates--a publication of the Women's Health and Aging Studies. Journal of Nutrition. 2006 Jan;136(1):172-6. Ray AL, Semba RD, Walston J., Ferrucci L, Cappola AR, Ricks MO, Xue QL, Fried LP. The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

 

Researchers at the German Institute of Human Nutrition determine that the association of decreased cancer risk with intake of cruciferous vegetables and selenium is stronger than that reported for fruits and vegetables in general. From dietary antioxidants to regulators in cellular signaling and gene regulation: Sulforaphane and selenium, partners in adaptive response and prevention of cancer. Free Radical Research. 2006 Aug;40(8):775-87. Brigelius-Flohe R., Banning A. German Institute of Human Nutrition, Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114 - 116, D-14558, Nuthetal, Germany.

 

Researchers in the UK demonstrate that selenium and sulforaphane synergize in their antioxidative activity. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis, 2003 Mar;24(3):497-503. Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK. Zhang J, Svehikova V., Bao Y, Howie AF, Beckett GJ, Williamson G. Click here for the BBC Report covering this publication.

 

A landmark preclinical nutrition study shows that a combined diet of broccoli and tomatoes has significant health promoting effects on prostate cells. Combinations of Tomato and Broccoli Enhance Antitumor Activity in Dunning R3327-H Prostate Adenocarcinomas. Canene-Adams K, Lindshield B, Wang S, Jeffery E, Clinton S, Erdman J., Cancer Research 2007; 67: (2). January 15, 2007

 

Groundbreaking clinical trial demonstrates that selenium supplementation can help support the immune system. Suppression of human immunodeficiency virus type 1 viral load with selenium supplementation: a randomized controlled trial. Archives of Internal Medicine. 2007 Jan 22;167(2):148-54. Hurwitz BE, Klaus JR, Lllabre MM, Gonzalez A, Lawrence PJ, Maher KJ, Greenson JM, Baum MK, Shor-Posner G, Skyler JS, Schneiderman N.

 

Scientists at the University of California, San Diego publish findings regarding selenium's immune enhancing properties. Selenium in the maintenance and therapy of HIV-infected patients. Chemical and Biological Interactions. 1994 Jun;91(2-3):199-205. Schrauzer GN, Sacher J. University of California, San Diego, Department of Chemistry and Biochemistry, La Jolla 92093.

 

Seminal epidemiology study conducted by researchers at the Massachusetts Eye and Ear Infirmary establishes a direct link between higher intakes of Lutein and Zeaxanthin and vision health. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. Journal of the American Medical Association.1994 Nov 9;272(18):1413-20. Seddon JM, Ajani UA, Sperduto RD, Hiller R, Blair N, Burton TC, Farber MD, Gragoudas ES, Haller J., Miller DT. Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Boston 02114.

 

British biomedical researchers report that supplementation with the carotenoids Lutein or Zeaxanthin improves human visual performance. Study Title: supplementation with the carotenoids lutein or zeaxanthin improves human visual performance. Ophthalmic & Physiological Optics. Kvansakul J, Rodriguez-Carmona M., Edgar DF, Barker FM, Kapcke W., Schalch W., Barbur JL. Applied Vision Research Centre, Department of Optometry and Visual Science, City University, London, UK.

 

Canadian biomedical researchers announce epidemiological evidence linking increased Lycopene intake to the reduction of oxidative stress. Lycopene. Advances in Food and Nutrition Research 2006;51:99-164. Rao AV, Ray MR, Rao LG, Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

 

Researchers at Tufts University publish the relationship between Vitamin E intake and enhanced immune function. Vitamin E and immune response in the aged: molecular mechanisms and clinical implications. Immonology Reviews. 2005 June;205:269-84. Meydani SN, Han SN, Wu D. Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA

 

Scientists at the Johns Hopkins School of Medicine publish an important study regarding sulforaphane and its promotion of gastrointestinal health - Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. 2002 May 28;99(11):7610-5. Proclamation of the National Academy of Sciences. Fahey JW, Haristoy X, Dolan PM, Kensler TW, Sholtus I, Stephenson KK, Talalay P, Lozniewski A. Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205-2185, USA.

 

Dr. Leonard Bjeldanes and Dr. Gary Firestone of UC Berkeley publish an important study elucidating the molecular biology of Diindolylmethane (DIM). Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression. Carcinogenesis. 2001 Nov;22(11):1809-17. Leong H, Firestone, GL, Bjeldanes LF. Department of Nutritional Sciences and Toxicology, University of California-Berkeley, Berkeley, CA 94720, USA.

  • Introducing ActivaMune with Patented
    Technology from UC Berkeley

  • Diindolylmethane (DIM)
    Imune, Breast, Prostate, Colon & Skin Health

  • Sulforaphane
    Cellular Detoxification

  • Selenium
    Immune, Breast, Prostate & Vision Health

  • Lycopene
    Cardiovascular, Breast & Prostate Health

  • Lutein
    Immune, Vision & Prostate Health

  • Zeaxanthin
    Vision Health

  • Vitamins C, D3, E and Calcium
    Immune Support & Bone Health

 

 

 

 

ActivaMune Poster Diindolylmethane DIM Natural Immune Booster

 

Note to Consumers

 

ActivaMune is a nutritional supplement. The statements made on this website have not been evaluated by the US Food and Drug Administration. The product featured is not intended to diagnose, treat, cure or prevent any disease. For medical advice please contact a licensed healthcare professional.

 

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